分析P—VEP的P100波及F—ERG的b波对白内障术后视功能的评估作用

来源:南粤论文中心 作者:蔡东梅 冷远梅 曹小川 发表于:2013-01-13 17:24  点击:
【关健词】视觉电生理;白内障术后;视功能评估
分析P—VEP的P100波及F—ERG的b波对白内障术后视功能的评估作用

Analysis of assessment effect of P-VEP P100 wave and F-ERG b wave for post-xataract surgery visual function
  CAI?Dongmei??LENG?Yuanmei??CAO?Xiaochuan??ZHAO?Jilie??FAN?Wenyi
  Department of Ophthalmology, Tongliang People's Hospital, Chongqing 402560, China
  [Abstract] Objective To evaluate the effect of preoperative integrated visual electrophysiological examination in predicting post-cataract surgery visual function assessment. Methods 146 patients with cataract, whose preoperative eyesight was more than 0.02, treated in our hospital from March 2011 to March 2012 were analyzed retrospectively. The eye with better eyesight was chosen in case of binocular surgery. Before the surgery, visual electrophysiological examination system TEC-350 was used to detect the pattern visual evoked potential and the flash electroretinogram, recording amplitude and latency of P100 wave and b-wave. The corrected vision was detected three days after the surgery, according to which the patients were divided into three groups: group A with eyesight <0.2 and 36 patients, group B with eyesight from 0.2-0.5 and 64 patients, and group C with eyesight >0.5 and 46 patients. The mean values of amplitude and latency of P100 wave and b wave of the three groups were calculated and compared. Results In group A, the mean value of P100 wave amplitude was(3.7±0.5)uV, the mean value of P100 wave latency was(112.3±20.1)ms, the mean value of b wave amplitude was (21.9±3.5)uV, the mean value of b wave latency was(56.6±18.4) ms. In group B, the mean value of P100 wave amplitude was(9.5±4.6)uV, the mean value of P100 wave latency was(100.5±22.2)ms, the mean value of b wave amplitude was(42.4±12.6)uV, the mean value of b wave latency was(56.2±15.4)ms. In group C, the mean value of P100 wave amplitude was(10.9±1.2)uV, the mean value of P100 wave latency was(98.5±17.4)ms, the mean value of b wave amplitude was(45.6±19.4)uV, the mean value of b wave latency was(55.2±10.4)ms. There existed statistical differences between the three groups, with statistically significant difference between group A and group B, and group A and group C in the P100 wave amplitude and latency, and b wave amplitude, without statistically significant difference in b wave latency, and without statistically significant difference between group B and group C in P100 and b wave amplitude and latency. Conclusion Analysis of the amplitude and latency of P100 wave of P-VEP and b wave of F-ERG has certain directive effect on the visual function assessment after cataract surgery. [Key words] Visual electrophysiology; Post-cataract surgery; Visual function assessment
  白内障患者术后效果差别很大,如果在术前能够预测到,预先告知患者,可以避免医患纠纷。术前眼B超、光定位等检查可以粗略估计术后效果,就要求有一个更精确的方法。近年来,眼电生理在白内障患者术后视力评估中应用的越来越广泛。本研究对73例患者进行了F-ERG和P-VEP检查,分析b波及P100波对白内障患者术后视力的评估作用。
  1?资料与方法
  1.1?一般资料
  回顾笔者所在医院2011年3月~2012年3月白内障患者146例,其中男76例,女70例,平均年龄(65.4±12.2)岁,术前视力>0.02,双眼手术患者选用术前视力较好眼,
  1.2?方法
  1.2.1?仪器?应用重庆泰克公司TEC-350视觉电生理检查系统作为记录系统。电极为银质盘状皮肤电极。
  1.2.2?检查方法
  1.2.2.1?闪光视网膜电图(F-ERG)?检查时,瞳孔散大至≥8 mm时,暗适应30 min后,按国际标准安放电极,信号电极置于近下睑缘皮肤处,地极置于前额正中,参考电极置于眼角外1 cm处。在绝对暗室,采用全视野白色闪光刺激,闪光强度为3.5 cd/(m2·s),检测记录。单个刺激频率≤1 Hz,平均刺激16次。
  1.2.2.2?图形翻转视觉诱发电位(P-VEP)?检查时,患眼为自然瞳孔状,电极安放按国际临床视觉电生理学会标准要求,信号电极置于枕骨粗隆上方2 cm处,地极置于前额正中,参考电极置于耳背隆骨下方。采用全视野16×16黑白棋盘格翻转刺激,刺激平均次数100次。经计算机平均叠加待波形稳定后记录。
  1.3?观察指标
  检测图形视诱发电位和闪光视网膜电流图,记录P100波及b波的振幅及潜伏期。
  1.4?统计学处理
  采用EpiData 3.0进行数据录入,应用SPSS13.0进行数据分析,多组计量资料比较,采用单因素方差分析,组间比较采用LSD检验,以P<0.05为差异有统计学意义。
  2?结果
  A组P100波振幅平均值(3.7±0.5)uV,潜伏期平均值(112.3±20.1)ms,b波振幅平均值(21.9±3.5)uV,潜伏期平均值(56.6±18.4)ms;B组P100波振幅平均值(9.5±4.6)uV,潜伏期平均值(100.5±22.2)ms,b波振幅平均值(42.4±12.6)uV,潜伏期平均值(56.2±15.4)ms;C组P100波振幅平均值(10.9±1.2)uV,潜伏期平均值(98.5±17.4)ms,b波振幅平均值(45.6±19.4)uV,潜伏期平均值(55.2±10.4)ms;3组之间比较差异有统计学意义(P<0.05);A组与B组﹑A组与C组之间P100的振幅及潜伏期﹑b波的振幅比较,差异有统计学意义(P<0.05),b波的潜伏期差异无统计学意义(P>0.05);B组与C组之间P100波及b波振幅及潜伏期比较,差异无统计学意义(P>0.05)。
  3?讨论
  如何在手术前客观评价老年性白内障患者视功能,术后能否达到预期增加视力目的,为术者所关心。白内障由于屈光介质混浊,不能直接看到眼底情况,需要借助一些检查方法了解眼底视功能。眼电生理可以评估眼底视功能,从而预测白内障术后视力。视觉电生理检查是一种无创伤的客观检测手段,较少受屈光间质浑浊的影响,由于P-VEP、F-ERG各自的局限性和互补性,联合使用优于任何单一的检查,可以得到更多的有关视功能的信息,对于是否有手术治疗价值为临床提供依据[1]。(责任编辑:南粤论文中心)转贴于南粤论文中心: http://www.nylw.net(南粤论文中心__代写代发论文_毕业论文带写_广州职称论文代发_广州论文网)

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